# NAD+ bibliography

> Research shelf | Shop Vital Peptides — The Shop Vital Peptides reading list: NAD+ demand in mouse immune cells, consumption, precursor metabolism and human muscle outcomes.

**The reading shelf**

The papers range from activated mouse immune cells to human trials. Their different settings are part of what makes the collection interesting.

## Inflammation

Start with [the dependence of inflammatory mouse macrophages on NAD+ salvage](https://pubmed.ncbi.nlm.nih.gov/30858618/), then read [the experiment in which NAD+ depletion primed NLRP3 activation](https://pubmed.ncbi.nlm.nih.gov/34987507/). I value the friction between them: supply and demand change with the cellular condition.

## Consumption and precursor metabolism

The [overview of NAD+ metabolism](https://pubmed.ncbi.nlm.nih.gov/33353981/) gives the shared pool its wider setting. [PARP1 and DNA repair](https://pubmed.ncbi.nlm.nih.gov/25283336/) supplies the consumption account; [mouse host–microbiome tracing](https://pubmed.ncbi.nlm.nih.gov/36476934/) makes the incoming route more circuitous.

## Human outcomes

The [NMN trial in prediabetic women](https://pubmed.ncbi.nlm.nih.gov/33888596/) and [trial reporting improved walking distance](https://pubmed.ncbi.nlm.nih.gov/36482258/) offer specific favourable results. Read them alongside the [review of human clinical evidence and its limitations](https://pubmed.ncbi.nlm.nih.gov/41083806/). The full titles follow below.

## References

[1] Inflammatory macrophage dependence on NAD(+) salvage is a consequence of reactive oxygen species-mediated DNA damage https://pubmed.ncbi.nlm.nih.gov/30858618/
[2] Intracellular NAD(+) Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation https://pubmed.ncbi.nlm.nih.gov/34987507/
[3] NAD+ metabolism and its roles in cellular processes during ageing https://pubmed.ncbi.nlm.nih.gov/33353981/
[4] NAD⁺ in aging, metabolism, and neurodegeneration. https://pubmed.ncbi.nlm.nih.gov/26785480/
[5] The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. https://pubmed.ncbi.nlm.nih.gov/20007326/
[6] ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death https://pubmed.ncbi.nlm.nih.gov/25283336/
[7] Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women https://pubmed.ncbi.nlm.nih.gov/33888596/
[8] The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial https://pubmed.ncbi.nlm.nih.gov/36482258/
[9] CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism https://pubmed.ncbi.nlm.nih.gov/27304511/
[10] NAD(+) precursor supplementation in human ageing: clinical evidence and challenges https://pubmed.ncbi.nlm.nih.gov/41083806/
[11] NAD precursors cycle between host tissues and the gut microbiome. https://pubmed.ncbi.nlm.nih.gov/36476934/
[12] Nicotinamide riboside kinase structures reveal new pathways to NAD+ https://pubmed.ncbi.nlm.nih.gov/17914902/
[13] Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities. https://pubmed.ncbi.nlm.nih.gov/31862890/
[14] NAD(+) homeostasis in human health and disease. https://pubmed.ncbi.nlm.nih.gov/34041853/
[15] NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. https://pubmed.ncbi.nlm.nih.gov/18020963/

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At Shop Vital Peptides, published research sets the terms of my inquiry into cellular demand; this editorial site conducts no business and offers no medical advice.