The reading shelf
NAD+ bibliography
The papers range from activated mouse immune cells to human trials. Their different settings are part of what makes the collection interesting.
Inflammation
Start with the dependence of inflammatory mouse macrophages on NAD+ salvage, then read the experiment in which NAD+ depletion primed NLRP3 activation. I value the friction between them: supply and demand change with the cellular condition.
Consumption and precursor metabolism
The overview of NAD+ metabolism gives the shared pool its wider setting. PARP1 and DNA repair supplies the consumption account; mouse host–microbiome tracing makes the incoming route more circuitous.
Human outcomes
The NMN trial in prediabetic women and trial reporting improved walking distance offer specific favourable results. Read them alongside the review of human clinical evidence and its limitations. The full titles follow below.
- Inflammatory macrophage dependence on NAD(+) salvage is a consequence of reactive oxygen species-mediated DNA damage ↗
- Intracellular NAD(+) Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation ↗
- NAD+ metabolism and its roles in cellular processes during ageing ↗
- NAD⁺ in aging, metabolism, and neurodegeneration. ↗
- The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. ↗
- ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death ↗
- Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women ↗
- The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial ↗
- CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism ↗
- NAD(+) precursor supplementation in human ageing: clinical evidence and challenges ↗
- NAD precursors cycle between host tissues and the gut microbiome. ↗
- Nicotinamide riboside kinase structures reveal new pathways to NAD+ ↗
- Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities. ↗
- NAD(+) homeostasis in human health and disease. ↗
- NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. ↗